Search on: BLOCKING AGENTS, NEUROMUSCULAR 
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Descriptor English:   Neuromuscular Blocking Agents 
Descriptor Spanish:   Bloqueantes Neuromusculares 
Descriptor Portuguese:   Bloqueadores Neuromusculares 
Synonyms English:   Neuromuscular Blockers
Agents, Neuromuscular Blocking
Blockers, Neuromuscular
Blocking Agents, Neuromuscular  
Tree Number:   D27.505.696.663.700.710
Definition English:   Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc. 
Indexing Annotation English:   GEN or unspecified; prefer specifics; consider also NEUROMUSCULAR JUNCTION /drug eff
History Note English:   75; was see under CURARE-LIKE AGENTS & NEUROMUSCULAR DEPOLARIZING AGENTS 1970-74 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   9658 
Unique Identifier:   D009466 

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